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Product Name
NPR2 antibody
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Description
NPR2 Rabbit Polyclonal antibody. Positive WB detected in transfected cells. Observed molecular weight by Western-blot: 111 kDa, 117 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
AMDM antibody; ANP B antibody; ANPR B antibody; ANPRB antibody; GC B antibody; Guanylate cyclase B antibody; GUC2B antibody; GUCY2B antibody; Natriuretic Peptide Receptor B antibody; NPR2 antibody; NPRB antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_003995). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
0.1M NaHCO3, 0.1M glycine, 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
WB result of anti-NPR2 (Catalog No:113220, 1:1000) with HEK293 overexpressed NPR2 by Jeremy Egbert and Laurinda Jaffe. (Another anti serum 6328 as control)
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Background
NPR2, also named as ANPRB, GC-B, NPR-B, ANPR-B and ANP-B, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. It is a receptor for the C-type natriuretic peptide NPPC/CNP hormone. NRP2 has guanylate cyclase activity upon binding of its ligand. It may play a role in the regulation of skeletal growth. NPR2 is the primary receptor for C type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM). The antibody is specific to NPR2.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"