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Product Name
NPBWR2 antibody
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Description
NPBWR2 Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
G protein coupled receptor 8 antibody; GPR8 antibody; neuropeptides B/W receptor 2 antibody; NPBWR2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of NPBWR2 recombinant protein (Accession Number: NM_005286). Purification method: Antigen Affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:50-1:500
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Validations
Immunohistochemistry of paraffin-embedded human brain tissue slide using Catalog No:113208(NPBWR2 Antibody) at dilution of 1:100 (under 10x lens).
Immunohistochemistry of paraffin-embedded human brain tissue slide using Catalog No:113208(NPBWR2 Antibody) at dilution of 1:100 (under 40x lens).
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Background
NPBWR1 (GPR7) and NPBWR2 (GPR8) are two structurally related G-protein coupled receptors. These two receptors share high sequence identity to each other and significant similarity with opioid and somatostatin receptors (PMID: 10407191). Neuropeptide B (NPB) and neuropeptide W (NPW) are endogenous peptide ligands of these receptors. NPBWR1 was found highly conserved in both human and rodents while NPBWR2 gene was not found in the rodent genomes (PMID: 7590751; 10407191). NPBWR1 and NPBWR2 are implicated in energy homeostasis, pain, and emotion (PMID: 23515889).
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