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Product Name
NOD2 antibody
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Description
NOD2 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, COLO 320 cells, U-937 cells, RAW264.7 cells. Observed molecular weight by Western-blot: 100-110kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse; other species not tested.
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Alternative names
NOD2 antibody; IBD1 antibody; CLR16.3 antibody; CARD15 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_022162). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:113290(NOD2 antibody) at dilution of 1:800
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Background
NOD2, also named as CARD15 and IBD1, induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. It confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Defects in NOD2 are the cause of Blau syndrome (BS). Defects in NOD2 are a cause of susceptibility to Crohn disease (CD). Defects in NOD2 are a cause of susceptibility to ulcerative colitis. Defects in NOD2 are the cause of early-onset sarcoidosis (EOS). The antibody is specific to NOD2.
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References
- Du P, Fan B, Han H. NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy. Kidney international. 84(2):265-76. 2013.
- Han H, Wang Y, Li X. Novel role of NOD2 in mediating Ca2+ signaling: evidence from NOD2-regulated podocyte TRPC6 channels in hyperhomocysteinemia. Hypertension. 62(3):506-11. 2013.
- Li X, Li F, Chu Y. NOD2 deficiency protects against cardiac remodeling after myocardial infarction in mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 32(6):1857-66. 2013.
- Shang J, Wan Q, Wang X. Identification of NOD2 as a novel target of RNA-binding protein HuR: evidence from NADPH oxidase-mediated HuR signaling in diabetic nephropathy. Free radical biology & medicine. 79:217-27. 2015.
- Zhou M, Tang W, Fu Y. Progranulin protects against renal ischemia/reperfusion injury in mice. Kidney international. 87(5):918-29. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"