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Product Name
NMDAR2A antibody
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Description
NMDAR2A Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Positive IF detected in Hela cells. Observed molecular weight by Western-blot: 150-160 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
GluN2A antibody; GRIN2A antibody; hNR2A antibody; NMDAR2A antibody; NR2A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_000833). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IF: 1:10-1:100
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113245(GRIN2A antibody) at dilution of 1:500
Immunofluorescent analysis of Hela cells, using GRIN2A antibody Catalog No:113245 at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
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Background
GRIN2A, also named as NMDAR2A and NR2A, belongs to the glutamate-gated ion channel (TC 1.A.10) family. GRIN2A is NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation of GRIN2A requires binding of agonist to both types of subunits. The antibody recognize the C-term of GRIN2A.
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References
- Priya A, Johar K, Wong-Riley MT. Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B. Biochimica et biophysica acta. 1833(12):2745-56. 2013.
- Deng L, Li G, Rao B, Li H. Central nervous system-specific knockout of Brg1 causes growth retardation and neuronal degeneration. Brain research. 1622:186-95. 2015.
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