Cynomolgus NKG2A / NKG2 / CD159A / KLRC1 (Fc Tag) recombinant protein

Cynomolgus NKG2A / NKG2 / CD159A / KLRC1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

NKG2, also known as NKG2A(CD159A), is a member of the killer cell lectin-like receptor family. This family is a group of transmembrane proteins preferentially expressed in NK cells. Members of this fmaily are characterized by the type II membrane orientation and the presence of a C-type lectin domain. NKG2 contains 1 C-type lectin domain and forms a complex with another family member, KLRD1/CD94. It is expressed only in NK-cells, but not in T-cells or B-cells. It has been shown that NKG2 represents a family of related cDNA clones, designated NKG2A, NKG2B, NKG2C, and NKG2D, which encode type 2 integral membrane proteins (extracellular C-terminus) containing a C-type lectin domain. Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NKG2 functions as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

NKG2-A-

C-LECTIN TYPE II PROTEIN; NATURAL KILLER CELL LECTIN; NKG2-A/B TYPE II INTEGRAL MEMBRANE PROTEIN; NK CELL RECEPTOR A; CD159 ANTIGEN-LIKE FAMILY MEMBER A; NKG2-A/NKG2-B TYPE II INTEGRAL MEMBRANE PROTEIN; MGC13374; NKG2-1/B ACTIVATING NK RECEPTOR; NKG2A; NKG2-A/B-ACTIVATING NK RECEPTOR; NATURAL KILLER GROUP PROTEIN 2; CD159A; NKG2; NKG2B; MGC59791

Q9MZJ2

NKG2; nkg2A

Human Cells

A DNA sequence encoding the cynomolgus KLRC1 (Q9MZJ2) (Pro94-Leu233) was expressed with the Fc region of human IgG1 at the N-terminus.

Cynomolgus

The recombinant cynomolgus KLRC1 is a disulfide-linked homodimer. The reduced monomer comprises 400 amino acids and has a calculated molecular mass of 44.4 KDa.The apparent molecular mass of the protein is approximately 47-55 KDa respectively in SDS-PAGE.

> 85 % as determined by SDS-PAGE