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Product Name
Human Nicastrin/NCSTN (His Tag) recombinant protein
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Description
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
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Protein name
Nicastrin
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Protein short names
KIAA0253; D1DAU13E; RP11-517F10.1; NCSTN; NCT; AA727311; APH2; NICASTRIN; 9430068N19RIK; MKIAA0253
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Uniprot ID
Q92542
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Gene Name
NCSTN; KIAA0253; UNQ1874/PRO4317
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human NCSTN (NP_056146.1) extracellular domain (Met 1-Glu 669) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human NCSTN consists of 647 amino acids and predictes a molecular mass of 72.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NCSTN is approximately 110-120 kDa due to glycosylation.
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Purity
> 93 % as determined by SDS-PAGE
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Validations
Human Nicastrin / NCSTN Protein (His Tag) SDS-PAGE
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