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Product Name
Mouse Nicastrin/NCSTN (Fc Tag) recombinant protein
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Description
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
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Protein name
Nicastrin
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Protein short names
KIAA0253; NCSTN; RP11-517F10.1; NCT; D1DAU13E; NICASTRIN; APH2; AA727311; MKIAA0253; 9430068N19RIK
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Uniprot ID
P57716
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Gene Name
Ncstn
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse NCSTN (P57716) (Met1-Glu668) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse NCSTN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 882 amino acids and has a predicted molecular mass of 98.5 kDa. The apparent molecular mass of the protein is approximately 117 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Mouse Nicastrin / NCSTN Protein (Fc Tag) SDS-PAGE
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