Mouse Nicastrin/NCSTN (Fc Tag) recombinant protein

Cat.#: 502089

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Product Information

  • Product Name
    Mouse Nicastrin/NCSTN (Fc Tag) recombinant protein
  • Documents
  • Description
    Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
  • Protein name
    Nicastrin
  • Protein short names
    KIAA0253; NCSTN; RP11-517F10.1; NCT; D1DAU13E; NICASTRIN; APH2; AA727311; MKIAA0253; 9430068N19RIK
  • Uniprot ID
    P57716
  • Gene Name
    Ncstn
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse NCSTN (P57716) (Met1-Glu668) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse NCSTN/Fc is a disulfide-linked homodimer. The reduced monomer comprises 882 amino acids and has a predicted molecular mass of 98.5 kDa. The apparent molecular mass of the protein is approximately 117 kDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Mouse Nicastrin / NCSTN Protein (Fc Tag) SDS-PAGE

    Mouse Nicastrin / NCSTN Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"