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  • NFKBIZ Polyclonal Antibody
  • NFKBIZ Polyclonal Antibody

NFKBIZ Polyclonal Antibody

Cat.#: 160527

Special Price 174.2 USD

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Product Information

  • Product Name
    NFKBIZ Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to NFKBIZ
  • Tested applications
    WB, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    NFKBIZ antibody; IKBZ antibody; INAP antibody; MAIL antibody; NFKB inhibitor zeta antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human NFKBIZ (NP_113607.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IF 1:50 - 1:200
  • Validations

    Western blot - NFKBIZ Polyclonal Antibody

    Western blot - NFKBIZ Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using NFKBIZ antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 10s.

    Immunofluorescence - NFKBIZ Polyclonal Antibody

    Immunofluorescence - NFKBIZ Polyclonal Antibody

    Immunofluorescence analysis of Raw264.7 cells using NFKBIZ antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

  • Background
    Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity).
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"