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NFKBIZ antibody

Cat.#: 113161

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Product Information

  • Product Name
    NFKBIZ antibody
  • Documents
  • Description
    NFKBIZ Rabbit Polyclonal antibody. Positive WB detected in HeLa cells. Positive IF detected in HeLa cells. Observed molecular weight by Western-blot: 64 kDa
  • Tested applications
    ELISA, WB, IF
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    FLJ30225 antibody; FLJ34463 antibody; I kappa B zeta antibody; IkappaB zeta antibody; IkappaBzeta antibody; IkB zeta antibody; IKBZ antibody; INAP antibody; IκBζ antibody; MAIL antibody; NF kappa B inhibitor zeta antibody; NFKBIZ antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of NFKBIZ recombinant protein (Accession Number: NM_031419). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IF: 1:50-1:500

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113161(NFKBIZ Antibody) at dilution of 1:300

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:113161(NFKBIZ Antibody) at dilution of 1:300

    Immunofluorescent analysis of (10% Formaldehyde) fixed HeLa cells using Catalog No:113161(NFKBIZ Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

    Immunofluorescent analysis of (10% Formaldehyde) fixed HeLa cells using Catalog No:113161(NFKBIZ Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

  • Background
    NFKBIZ, also named as NF-kappa-B inhibitor zeta, is a 718 amino acid protein, which contains 7 ANK repeats and is expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. NFKBIZ exists as three isoforms and molecular weight of isoform three is a 64 kDa. The isoform one is 78 kDa protein and isoform two is a 68kDa protein protein. NFKBIZ is involved in regulation of NF-kappa-B transcription factor complexes. It Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation.
  • References
    • Xu D, Hu L, Su C. Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin. Toxicology and applied pharmacology. 280(2):305-13. 2014.
    • Zhang Y, Li R, Zhu J, Wang Z, Lv S, Xiong JY. Etomidate increases mortality in septic rats through inhibition of nuclear factor kappa-B rather than by causing adrenal insufficiency. The Journal of surgical research. 193(1):399-406. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"