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Product Name
Human NCF2 / NCF-2 / P67phox recombinant protein
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Description
NCF2, also known as NCF-2 and p67phox, is a subunit of the multi-protein NADPH oxidase complex. NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in NCF2 gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms.
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Protein name
Neutrophil cytosol factor 2
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Protein short names
P67PHOX; RP1-127C7.5; NCF-2; NEUTROPHIL CYTOSOLIC FACTOR 2 (65KD; NEUTROPHIL CYTOSOLIC FACTOR 2; AUTOSOMAL 2; NADPH OXIDASE ACTIVATOR 2; AUTOSOMAL 2); 67 KDA NEUTROPHIL OXIDASE FACTOR; NEUTROPHIL CYTOSOL FACTOR 2; CHRONIC GRANULOMATOUS DISEASE; NOXA2; NEUTROPHIL NADPH OXIDASE FACTOR 2; NADPH OXIDASE SUBUNIT (67 KD); CHRONIC GRANULOMATOUS DISEASE; NCF2; NADPH OXIDASE SUBUNIT (67KDA); P67-PHOX
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Uniprot ID
P19878
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Gene Name
NCF2; NOXA2; P67PHOX
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human NCF2 (AAH01606.1) (Met1-Val526) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.
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Protein Species
Human
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Molecular weight
The secreted recombinant human NCF2 consists of 528 amino acids and predicts a molecular mass of 59.9 KDa. The apparent molecular mass of the protein is approximately 60 KDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 85 % as determined by SDS-PAGE
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Validations
Human NCF2 / NCF-2 / P67phox Protein SDS-PAGE
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