Neuromedin U-25 (human) peptide
Not For Human Use, Lab Use Only.
Cat.#: 307692
Special Price 316.2 USD
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Product Name
Neuromedin U-25 (human) peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
FRVDEEFQSPFASQSRGYFLFRPRN
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Sequence
H-Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2
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Length (aa)
25
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Peptide Purity (HPLC)
97.6%
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Molecular Formula
C141H203N41O38
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Molecular Weight
3080.42
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Source
Synthetic
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Form
Powder
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Description
Neuromedin U is a neuropeptide which is widely distributed in the gut and central nervous system. Initially isolated from porcine spinal cord it was named for its uterine contractile activity. In fasted rats neuromedin U expression in certain brain areas is lower than in fed rats. In animal studies with neuromedin-23 (rat) overnight food intake is significantly reduced indicating that neuromedin U may be a physiological regulator of food intake. IC50 values for the binding
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- M.Honzawa et al., Neuroscience, 23, 1103 (1987)
- J.Ballesta et al., Neuroscience, 25, 797 (1988)
- A.D.Howard et al., Nature, 406, 70 (2000)
- K.Ketterer et al., Cancer Lett., 277, 72 (2008)
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Peptide Property
- Analysed Sequence:H-FRVDEEFQSPFASQSRGYFLFRPRN-Amidation
- Chemical Formula:C141H203N41O38
- Sequence length:25
- Extinction coefficient:1280 M-1cm-1
- GRAVY:-0.9
- Mw average:3080.36
- Theoretical pI:9.84
- Data Source:Peptide Property Calculator
GRAVY = grand average of hydropathy
X: Hydrophobic uncharged residues, like F I L M V W A and P
X: Basic residues, like R K H
X: Acidic residues, like D E
X: Polar uncharged residues, like G S T C N Q and Y
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"