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neuromedin B antibody

Cat.#: 113130

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Product Information

  • Product Name
    neuromedin B antibody
  • Documents
  • Description
    neuromedin B Rabbit Polyclonal antibody. Positive IHC detected in human brain tissue, human breast cancer tissue, human skin tissue, human stomach tissue.
  • Tested applications
    ELISA, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    neuromedin B antibody; NMB antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of neuromedin B recombinant protein (Accession Number: NM_205858). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    IHC: 1:10-1:100

  • Validations

    Immunohistochemical of paraffin-embedded human brain using Catalog No:113130(NMB antibody) at dilution of 1:25 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:113130(NMB antibody) at dilution of 1:25 (under 10x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:113130(NMB antibody) at dilution of 1:25 (under 40x lens)

    Immunohistochemical of paraffin-embedded human brain using Catalog No:113130(NMB antibody) at dilution of 1:25 (under 40x lens)

  • Background
    Neuromedin B (NMB) is a bombesin-like peptide, which inhibits food intake and modulates stress-related behaviour. It exerts its function via NMB receptor (NMB-R). NMB is encoded in a 76-amino acid precursor. The mature NMB was reported to be a 10-amino-acid peptide, giving two bands of 1.2 kDa and 1.5 kDa in western blotting. NMB is expressed in brain, gastrointestinal tract, pancreas, adrenals, and adipose tissue. It regulates exocrine and endocrine secretions, cell growth, body temperature and blood pressure and glucose level in vivo.
  • References
    • Allman JM, Tetreault NA, Hakeem AY. The von Economo neurons in frontoinsular and anterior cingulate cortex in great apes and humans. Brain structure & function. 214(5-6):495-517. 2010.
    • Stimpson CD, Tetreault NA, Allman JM. Biochemical specificity of von Economo neurons in hominoids. American journal of human biology : the official journal of the Human Biology Council. 23(1):22-8. 2010.
    • Park HJ, Kim SR, Kim MK. Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo. Cancer letters. 312(1):117-27. 2011.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"