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Product Name
Human Neuroligin 1/NLGN1 (His Tag) recombinant protein
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Description
Brorin, also known as brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2 and VWC2, is a secreted protein which contains two VWFC domains. VWC2 / Brorin is a BMP antagonist which may play a role in neural development. It promotes cell adhesion. VWC2 / Brorin is a unique member of the chordin family. It inhibited the activity of bone morphogenetic protein 2 (BMP2) and BMP6 in mouse preosteoblastic MC3T3-E1 cells. Mouse Brorin was predominantly expressed in neural tissues in embryos and also predominantly expressed in the adult brain. In the brain, the expression was detected in neurons, but not glial cells. The neural tissue-specific expression profile of Brorin is quite distinct from that of any other member of the Chordin family. VWC2 / Brorin protein promoted neurogenesis, but not astrogenesis, in mouse neural precursor cells. VWC2 / Brorin is a novel secreted BMP antagonist that potentially plays roles in neural development and functions.
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Protein name
Neuroligin-1
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Protein short names
G11; RP23-305B2.1; MGC131845; VWC2; UNQ739/PRO1434; PSST739; CRADIN; A930041G11RIK; UNQ739
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Uniprot ID
Q8N2Q7
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Gene Name
NLGN1; KIAA1070
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human NLGN1 (NP_055747.1) extracellular domain (Met 1-Ser 677) was expressed, fused with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human NLGN1 consists of 643 amino acids and predictes a molecular mass of 72 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhNLGN1 is approximately 85-95 kDa due to glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Human Neuroligin 1 / NLGN1 Protein (His Tag) SDS-PAGE
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