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Product Name
Mouse Neuroligin 1/NLGN1 (His Tag) recombinant protein
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Description
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and sleep (PubMed:23716671).
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Protein name
Neuroligin-1
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Protein short names
BB179718; 6330415N05RIK; KIAA1070; MGC45115; NLGN1; MGC107366; NEUROLIGIN 1; MKIAA1070; NL1; NLG1
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Uniprot ID
Q99K10
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Gene Name
Nlgn1; Kiaa1070
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mouse NLGN1 isoform 1 (Q99K10-1) extracellular domain (Met 1-Ser 697) was expressed, with a C-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The recombinant mouse NLGN1 consists of 671 amino acids and predicts a molecular mass of 73.5 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmNLGN1 is approximately 100-110 KDa as a result of glycosylation.
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Purity
> 97 % as determined by SDS-PAGE
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Validations
Mouse Neuroligin 1 / NLGN1 Protein (His Tag) SDS-PAGE
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