NEUROD1 antibody

NEUROD1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

NEUROD1 Rabbit Polyclonal antibody. Positive IP detected in Y79 cells. Positive WB detected in Y79 cells. Positive IHC detected in human pancreas cancer tissue. Observed molecular weight by Western-blot: 50 kDa

ELISA, IHC, WB, IP

Human,Mouse,Rat; other species not tested.

BETA2 antibody; BHF 1 antibody; bHLHa3 antibody; NEUROD antibody; NEUROD1 antibody; neurogenic differentiation 1 antibody

Rabbit IgG

This antibody was obtained by immunization of NEUROD1 recombinant protein (Accession Number: NM_002500). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

NeuroD is a member of the basic helix-loop-helix (bHLH) family of transcription factors. The basic helix-loop-helix (bHLH) proteins are transcription factors that are required for several aspects of development, including cell type determination, terminal differentiation and sex determination. Members of the myogenic determination family, MyoD, myf5, myogenin and MRF4, all have bHLH domains.These proteins function by forming heterodimers with E-proteins and binding to the canonical E-box sequence CANNTG. Neuro D is expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation into mature neurons. Moreover, ectopic expression of Neuro D in Xenopus embryos induces premature differentiation of neuronal precursors and Neuro D can convert presumptive epidermal cells into neurons.The lack of NeuroD in the brain results in severe defects in development. Human mutations have been linked to a number of types of diabetes including type I diabetes mellitus and maturity-onset diabetes of the young.

• Chen C, Ma Q, Liu C. Exposure to 1800 MHz radiofrequency radiation impairs neurite outgrowth of embryonic neural stem cells. Scientific reports. 4:5103. 2014.