NDP Polyclonal Antibody

NDP Polyclonal Antibody

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Polyclonal antibody to NDP

IHC

Rat

NDP antibody; EVR2 antibody; FEVR antibody; ND antibody; norrin antibody

Rabbit IgG

Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-133 of human NDP (NP_000257.1).

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.

IHC 1:50 - 1:100

Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.