NDEL1 antibody

NDEL1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

NDEL1 Rabbit Polyclonal antibody. Positive IP detected in HepG2 cells. Positive WB detected in human brain tissue, HepG2 cells. Observed molecular weight by Western-blot: 38-42kd

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

DKFZp451M0318 antibody; EOPA antibody; MITAP1 antibody; Mitosin assOCiated protein 1 antibody; NDEL1 antibody; NUDEL antibody; Protein Nudel antibody

Rabbit IgG

This antibody was obtained by immunization of NDEL1 recombinant protein (Accession Number: XM_017025185). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Nuclear distribution factor E-homolog 1 (NDE1), NDE-like 1 (NDEL1), and Lissencephaly 1 (LIS1) together involve in essential neurodevelopmental processes, including neuronal precursor proliferation and differentiation, neurite outgrowth, and neuronal migration. All three bind directly to Disrupted in Schizophrenia 1 (DISC1), a scaffold protein critical to neuronal proliferation, integration, migration, and synaptic function within the developing and adult brain.[PMID: 18469341] Nuclear distribution element-like 1 (NDEL1) was firstly identified as a regulator of the cytoskeleton in microtubule and intermediate fliament dynamics and microtubule-based transport [PMID:21948775]. It is required for organization of the cellular microtubule array and microtubule anchoring at the centrosome, which is in part by targeting the microtubule severing protein KATNA1 to the centrosome[PMID:15728732].

• Sumigray KD, Chen H, Lechler T. Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. The Journal of cell biology. 194(4):631-42. 2011.