Product Name

NCS1 antibody

Documents

Description

NCS1 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, A431 cells, HepG2 cells, human brain tissue, mouse cerebellum tissue, PC-3 cells, rat brain tissue, SH-SY5Y cells. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 22 kDa

Tested applications

ELISA, WB, IP

Species reactivity

Human,Mouse,Rat; other species not tested.

Alternative names

DKFZp761L1223 antibody; FLUP antibody; FREQ antibody; Frequenin homolog antibody; frequenin homolog (Drosophila) antibody; Frequenin like protein antibody; NCS 1 antibody; NCS1 antibody; Neuronal calcium sensor 1 antibody

Isotype

Rabbit IgG

Preparation

This antibody was obtained by immunization of NCS1 recombinant protein (Accession Number: NM_014286). Purification method: Antigen affinity purified.

Clonality

Polyclonal

Formulation

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions

Store at -20℃. DO NOT ALIQUOT

Applications

Recommended Dilution:

WB: 1:1000-1:10000

IP: 1:500-1:5000

Validations

mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:113048(FREQ Antibody) at dilution of 1:2000

IP Result of anti-FREQ (IP:Catalog No:113048, 4ug; Detection:Catalog No:113048 1:1000) with mouse brain tissue lysate 4000ug.

Background

NCS1 is a member of the neuronal calcium sensor gene family. It regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity.

References

Mun HS, Saab BJ, Ng E. Self-directed exploration provides a Ncs1-dependent learning bonus. Scientific reports. 5:17697. 2015.
Saab BJ, Georgiou J, Nath A. NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. Neuron. 63(5):643-56. 2009.

NCS1 antibody

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