NCAM1/CD56 antibody

NCAM1/CD56 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

NCAM1/CD56 Mouse Monoclonal antibody. Positive WB detected in Human brain. Positive IHC detected in human lung cancer tissue. Observed molecular weight by Western-blot: 140 kDa

ELISA, WB, IHC

Human,Mouse; other species not tested.

CD56 antibody; MSK39 antibody; N CAM 1 antibody; NCAM antibody; NCAM 1 antibody; NCAM1 antibody

Mouse IgG1

This antibody was obtained by immunization of NCAM1/CD56 recombinant protein (Accession Number: NM_181351). Purification method: Protein G purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812). The glycosylphosphatidylinositol (GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats (FNIII). All three forms can be posttranslationally modified by addition of polysialic acid (PSA) (PMID: 14976519). Several other isofroms have also been described (PMID: 1856291).