NBN antibody

NBN antibody

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• Material Safety Data Sheets (MSDS)

NBN Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in HeLa cells, HEK-293 cells, HepG2 cells, human testis tissue, mouse brain tissue. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 90-95 kDa

ELISA, WB, IP, IF

Human,Mouse,Rat; other species not tested.

AT V1 antibody; AT V2 antibody; ATV antibody; FLJ10155 antibody; NBN antibody; NBS antibody; NBS1 antibody; nibrin antibody; P95 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_002485). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

NBN, also named as NBS, NBS1 and P95, is a component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. Defects in NBN are the cause of Nijmegen breakage syndrome (NBS). Defects in NBN are a cause of genetic susceptibility to breast cancer (BC). Defects in NBN may be associated with aplastic anemia. Defects in NBN might play a role in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). The antibody is specific to NBN.