Nav1.5 antibody

Nav1.5 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Nav1.5 Rabbit Polyclonal antibody. Positive WB detected in mouse heart tissue. Observed molecular weight by Western-blot: 227 kDa

ELISA, WB

Human, Mouse; other species not tested.

CDCD2 antibody; CMD1E antibody; CMPD2 antibody; HB1 antibody; HB2 antibody; HBBD antibody; HH1 antibody; ICCD antibody; IVF antibody; LQT3 antibody; Nav1.5 antibody; PFHB1 antibody; SCN5A antibody; SSS1 antibody

Rabbit IgG

This antibody was obtained by immunization of Nav1.5 recombinant protein (Accession Number: NM_001160160). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Voltage-gated sodium channels are responsible for initiation and propagation of action potentials in the membranes of neurons and most electrically excitable cells (PMID: 10798388). These channels are composed of a large alpha subunit that forms the ion conduction pore and auxiliary beta subunits (PMID: 11486343). The alpha subunits form a gene family with at least 10 members. Nav1.5, encoded by the SCN5A gene in humans, is a pore forming alpha subunit of voltage-gated sodium channels. Nav1.5 is the principal Na+ channel isoform expressed in cardiomyocytes. Mutations in SCN5A gene have been linked to many cardiac electrical disorders, including the congenital and acquired long QT syndrome, Brugada syndrome, conduction slowing, sick sinus syndrome, atrial fibrillation, and dilated cardiomyopathy (PMID: 23123192).