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NARFL-Specific antibody

Cat.#: 112952

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Product Information

  • Product Name
    NARFL-Specific antibody
  • Documents
  • Description
    NARFL-Specific Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells. Positive IHC detected in human kidney tissue, human heart tissue. Observed molecular weight by Western-blot: 26-28 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    FLJ21988 antibody; HPRN antibody; IOP1 antibody; LET1L antibody; NARFL antibody; PRN antibody; Protein related to Narf antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_022493). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:112952(NARFL-Specific antibody) at dilution of 1:800

    HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:112952(NARFL-Specific antibody) at dilution of 1:800

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:112952(NARFL-Specific antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:112952(NARFL-Specific antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:112952(NARFL-Specific antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:112952(NARFL-Specific antibody) at dilution of 1:100 (under 10x lens)

  • Background
    NARFL, also named as PRN and IOP1, belongs to the NARF family. NAFL is a component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. It is required for maturation of extramitochondrial Fe/S proteins. It seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. [18270200], [16956324] The antibody is specific to NARFL.
  • References
    • Corbin MV, Rockx DA, Oostra AB, Joenje H, Dorsman JC. The iron-sulfur cluster assembly network component NARFL is a key element in the cellular defense against oxidative stress. Free radical biology & medicine. 89:863-72. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"