Cynomolgus CD297 (Fc Tag) recombinant protein

Cynomolgus CD297 (Fc Tag) recombinant protein

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ADP-ribosyltransferase 4 (Dombrock blood group), also known as Mono-ADP-ribosyltransferase 4(ART4), Dombrock blood group carrier molecule and CD297, is a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. ART4 could be detected on HEL cells and erythrocytes by FACS analysis while it was absent from activated monocytes, despite the presence of ART4 mRNA in these cells. ART is also known as the carrier of the Dombrock blood group alloantigens (Do) which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane.

NAD(P)(+)--arginine ADP-ribosyltransferase

4432404K01RIK; MONO(ADP-RIBOSYL)TRANSFERASE; DOMBROCK BLOOD GROUP CARRIER MOLECULE; ADP-RIBOSYLTRANSFERASE 4 (DO BLOOD GROUP); NAD(P)(+)--ARGININE ADP-RIBOSYLTRANSFERASE 4; MONO(ADP-RIBOSYL)TRANSFERASE 4; ARTC4; ECTO-ADP-RIBOSYLTRANSFERASE 4; MONO-ADP-RIBOSYLTRANSFERASE 4; DO; DOK1; CD297

G7PJY0

EGM_03032

Human Cells

A DNA sequence encoding the cynomolgus ART4 (G7PJY0) (Thr31-Lys300) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus ART4 is a disulfide-linked homodimer. The reduced monomer comprises 480 amino acids and has a calculated molecular mass of 54.7 KDa.The apparent molecular mass of the protein is approximately 66 KDa respectively in SDS-PAGE.

> 95 % as determined by SDS-PAGE