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Product Name
MYSM1 Polyclonal Antibody
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Description
Polyclonal antibody to MYSM1
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Tested applications
WB, FC
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Species reactivity
Human, Mouse
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Alternative names
MYSM1 antibody; 2A-DUB antibody; 2ADUB antibody; histone H2A deubiquitinase MYSM1 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A synthetic peptide of human MYSM1
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, pH7.3.
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Storage instructions
Store at 4℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:1000
FC 1:20 - 1:50 -
Validations
Western blot - MYSM1 Polyclonal Antibody
Western blot analysis of extracts of HeLa cells, using MYSM1 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
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Background
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis and lymphocyte differentiation.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"