MYO7A antibody

MYO7A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MYO7A Rabbit Polyclonal antibody. Positive WB detected in L02 cells, A431 cells. Positive IF detected in HepG2. Observed molecular weight by Western-blot: 160-255kd

ELISA, WB, IF

human, mouse, rat; other species not tested.

MYO7A antibody; NSRD2 antibody; USH1B antibody; MYOVIIA antibody; DFNA11 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_000260). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MYO7A, also named a USH1B, is one of myosins protein which are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. In retina, MYO7A might play a role in trafficking of ribbon-synaptic vesicle complexes and renewal of the outer photoreceptors disks. In inner ear, it might maintain the rigidity of stereocilia during the dynamic movements of the bundle. It is involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Defects in MYO7A are the cause of Usher syndrome type 1B (USH1B). Defects in MYO7A are the cause of deafness autosomal recessive type 2 (DFNB2). Defects in MYO7A are the cause of deafness autosomal dominant type 11 (DFNA11). The antibody is specific to MYO7A.