MYLK antibody

MYLK antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MYLK Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells, Hela cells. Positive WB detected in mouse uterus tissue, mouse large intestine tissue. Observed molecular weight by Western-blot: 135kd

ELISA, WB, IF

Human,Mouse,Rat; other species not tested.

DKFZp686I10125 antibody; FLJ12216 antibody; Kinase related protein antibody; KRP antibody; MLCK antibody; MLCK1 antibody; MLCK108 antibody; MLCK210 antibody; MSTP083 antibody; MYLK antibody; MYLK1 antibody; myosin light chain kinase antibody; smMLCK antibody; Telokin antibody

Rabbit IgG

This antibody was obtained by immunization of MYLK recombinant protein (Accession Number: BC113456). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MYLK(Myosin light chain kinase) is also named as MLCK, MLCK1, MYLK1 and belongs to the protein kinase superfamily. It is a key enzyme in muscle contraction. Its activation is sufficient to enhance paracellular permeability and is required for tight junction barrier regulation in response to Na+-nutrient cotransport, inflammatory cytokines, or pathogenic bacteria(PMID:20404178). The expression of smooth muscle MYLK is tissue-specific. Smooth muscle MYLK generates three different proteins, long MYLK, short MYLK, and telokin. The 130-kDa smooth muscle, or short, MYLK (130 kDa) is expressed in smooth muscles. It has 8 isoforms produced by alternative splicing and alternative initiation and our anti-MYLK antibody can recognize these isforms.

• Sumagin R, Robin AZ, Nusrat A, Parkos CA. Transmigrated neutrophils in the intestinal lumen engage ICAM-1 to regulate the epithelial barrier and neutrophil recruitment. Mucosal immunology. 7(4):905-15. 2014.