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Product Name
MYH6 antibody
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Description
MYH6 Rabbit Polyclonal antibody. Positive IHC detected in human heart tissue, mouse heart tissue. Positive WB detected in rat heart tissue. Observed molecular weight by Western-blot: 200-220 kDa
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Tested applications
ELISA, IHC, WB
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Species reactivity
Human, Mouse, Rat; other species not tested.
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Alternative names
alpha MHC antibody; ASD3 antibody; MYH6 antibody; MYHC antibody; MyHC alpha antibody; MYHCA antibody; Myosin 6 antibody; Myosin heavy chain 6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_002471). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:2000-1:20000
IHC: 1:20-1:200
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Validations
rat heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:112935(MYH6 Antibody) at dilution of 1:5000
Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:112935(MYH6 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human heart tissue slide using Catalog No:112935(MYH6 Antibody) at dilution of 1:50 (under 40x lens)
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Background
MYH6 encodes the alpha-cardiac myosin heavy chain (aMHC) which is a major contractile protein exclusively expressed in the myocardium of the heart. Expression of MYH6 is down-regulated in cardiac myopathy and failing hearts. Defects in MYH6 lead to congenital heart disease (CHD), and a spectrum of phenotypes ranging from hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). (15737621, 20656787)
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