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Product Name
MYH4-Specific antibody
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Description
MYH4-Specific Rabbit Polyclonal antibody. Positive WB detected in human skeletal muscle tissue, mouse skeletal muscle tissue. Positive IHC detected in human skeletal muscle tissue. Observed molecular weight by Western-blot: 230kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
MYH2B antibody; MYH4 antibody; MyHC 2B antibody; MyHC IIb antibody; Myosin 4 antibody; Myosin heavy chain 2b antibody; Myosin heavy chain 4 antibody; Myosin heavy chain IIb antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_017533). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with Catalog No:112934(MYH4-Specific Antibody) at dilution of 1:300
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:112934(MYH4-Specific Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using Catalog No:112934(MYH4-Specific Antibody) at dilution of 1:50 (under 40x lens)
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Background
Myosin is one of the most important skeletal muscle proteins. MYH4 functions muscle contraction. The antibody is specific to MYH4.
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References
- Wang L, Chen X, Zheng Y. MiR-23a inhibits myogenic differentiation through down regulation of fast myosin heavy chain isoforms. Experimental cell research. 318(18):2324-34. 2012.
- Yuan H, Niu Y, Liu X, Yang F, Niu W, Fu L. Proteomic analysis of skeletal muscle in insulin-resistant mice: response to 6-week aerobic exercise. PloS one. 8(1):e53887. 2013.
- Yun SJ, Ha JM, Kim EK. Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells. Biochimica et biophysica acta. 1842(11):2184-92. 2014.
- Mastrocola R, Collino M, Nigro D. Accumulation of advanced glycation end-products and activation of the SCAP/SREBP Lipogenetic pathway occur in diet-induced obese mouse skeletal muscle. PloS one. 10(3):e0119587. 2015.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"