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Product Name
MTMR2 antibody
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Description
MTMR2 Rabbit Polyclonal antibody. Positive WB detected in human cerebellum tissue. Observed molecular weight by Western-blot: 66-68kd
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CMT4B antibody; CMT4B1 antibody; KIAA1073 antibody; MTMR2 antibody; myotubularin related protein 2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MTMR2 recombinant protein (Accession Number: NM_016156). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
human cerebellum tissue were subjected to SDS PAGE followed by western blot with Catalog No:112785(MTMR2 antibody) at dilution of 1:1000
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Background
MTMR2(myotubularin-related protein 2) is also named as KIAA1073 and belongs to the non-receptor class myotubularin subfamily, which is characterized by the presence of a phosphatase domain. It may regulate vesicular trafficking in Schwann cells(PMID:17880751) and its reversible phosphorylation represents a critical mechanism for regulating the subcellular localization of MTMR2(PMID:21372139). Mtmr2 is a 73 kDa protein in its monomeric form and exist as a dimer within cells and the protein re-localizes to membranes in hypo-osmotic settings(PMID:16399794). Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1).
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