MT1-MMP antibody

MT1-MMP antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MT1-MMP Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, A549 cells, COLO 320 cells, human colon tissue. Positive IF detected in COLO 320 cells. Observed molecular weight by Western-blot: 66 kDa,45-50 kDa

ELISA, WB, IF

Human,Mouse,Rat,Zebrafish; other species not tested.

Matrix metalloproteinase 14 antibody; MMP 14 antibody; MMP X1 antibody; MMP14 antibody; MT MMP 1 antibody; MT1 MMP antibody; MT1MMP antibody; MT1-MMP antibody; MTMMP1 antibody

Rabbit IgG

This antibody was obtained by immunization of MT1-MMP recombinant protein (Accession Number: NM_004995). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MMP14, also named as MT1-MMP, is a key matrix metalloproteinase (MMP) family member which plays a crucial role in tumor growth, invasion and metastasis. MT1-MMP is a cell membrane-bound proteinase, and it enhances degradation of collagen IV, a major component of the basement membrane, by forming a complex with tissue inhibitor of metalloproteinase-2 (TIMP-2) to activate pro-MMP-2. MT1-MMP can influence venous invasion, intrahepatic metastasis , and patient outcome in hepatocellular carcinoma (HCC). MT1-MMP was reported to be present in centromere and could lead to chromosome instability in MDCK cells, indicating that MT1-MMP may have more novel functions in the intracellular compartments. In western blotting, pro-MMP14 (65 kDa) and MMP14 (51 kDa) bands showed with the truncated MMP14 (45, 42, 35, 20 kDa) forms (PMID:12097451).