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MRP2 antibody

Cat.#: 112806

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Product Information

  • Product Name
    MRP2 antibody
  • Documents
  • Description
    MRP2 Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, mouse kidney tissue. Positive IHC detected in human small intestine tissue. Observed molecular weight by Western-blot: 190-250 kDa
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    ABC30 antibody; ABCC2 antibody; MRP2 antibody
  • Immunogen
    Human ABCC2 Recombinant protein (GST tag)
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of MRP2 recombinant protein (Accession Number: NM_000392). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:112806(ABCC2 Antibody) at dilution of 1:600

    HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:112806(ABCC2 Antibody) at dilution of 1:600

    Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:112806(ABCC2 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:112806(ABCC2 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:112806(ABCC2 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human small intestine tissue slide using Catalog No:112806(ABCC2 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    Multi-drug resistance protein 2 (MRP2), also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation. (16434545, 18834541, 23045960)
  • References
    • Zhou M, Huang Y, Cheng Z. Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes. Journal of virological methods. 207:29-37. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"