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Product Name
Mouse Kitlg/Kitl/Mgf/Sl/Slf recombinant protein
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Description
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.
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Protein name
kit ligand(Kitl)
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Protein short names
Kitl; Mgf; Sl; Slf
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Uniprot ID
P20826
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Mouse Kitlg/Kitl/Mgf/Sl/Slf Lys26-Ala189 is expressed.
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Protein Species
Mouse
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Purity
>95% as determined by SDS-PAGE.
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Validations
Mouse Kitlg/Kitl/Mgf/Sl/Slf recombinant protein
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