Mouse IL3 recombinant protein (Native)

Mouse IL3 recombinant protein (Native)

• DataSheet
• Material Safety Data Sheets (MSDS)

IL3 (interleukin 3), also known as IL-3, is a potent growth promoting cytokine which belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3/IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

Interleukin-3

BPA,Csfmu,HCGF,Il-3,MCGF,PSF

P01586

Interleukin-3; IL-3; Hematopoietic growth factor; Mast cell growth factor; MCGF; Multipotential colony-stimulating factor; P-cell-stimulating factor

Human Cells

A DNA sequence encoding the mouse IL3 (NP_034686.2) (Met1-Cys166) was expressed.

Mouse

The recombinant mouse IL3 consists of 140 amino acids and predicts a molecular mass of 15.7 kDa.

> 95 % as determined by SDS-PAGE.

Measured in a cell proliferation assay using NFS-60 mouse myelogenous leukemia lymphoblast cells. The ED₅₀ for this effect is 0.1-0.5 ng/mL.