-
Product Name
Mouse FSTL1 (His Tag) recombinant protein
- Documents
-
Description
Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently, we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here, we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling.
-
Protein name
Follistatin-related protein 1
-
Protein short names
FSL1; FLJ52277; FLJ50214; AI316791; FSTL; MIR198; TSC-36; AW107808; FSTL1; FRP
-
Uniprot ID
Q62356
-
Gene Name
Fstl1; Frp; Fstl; Tsc36
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the mouse FSTL1 (NP_032073.2) (Met1-Ile306) was expressed with a C-terminal polyhistidine tag.
-
Protein Species
Mouse
-
Molecular weight
The recombinant mouse FSTL1 comprises 299 amino acids and has a predicted molecular mass of 33.9 kDa. The apparent molecular mass of the protein is approximately 44.9 kDa in SDS-PAGE under reducing conditions.
-
Purity
> 95 % as determined by SDS-PAGE
-
Validations
Mouse FSTL1 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"