-
Product Name
Mouse Extl2/Extr2 (His tag) recombinant protein
- Documents
-
Description
Exostosin-like 2 (EXTL2) is a member of the exostosin (EXT)-related family which contains five members: EXT1, EXT2, EXTL1, EXTL2, and EXTL3. Studies have shown that EXT gene family members have the activities of heparan sulfate-synthesizing glycosyltransferases. EXT1 and EXT2, which have been identified as causal genes for hereditary multiple exostoses, have HS-GlcAT-II and GlcNAcT-II activities. EXTL1 has GlcNAcT-II activity and EXTL3 has GlcNAcT-I and -II activities. EXTL2 has GlcNAcT-I and N-acetylgalactosaminyltransferase activities, and transfers a GlcNAc residue to the tetrasaccharide linkage region when this region is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminate chain elongation. In mice, lack of EXTL2 causes glycosaminoglycan (GAG) overproduction and structural changes of GAGs associated with pathological processes.
-
Protein name
exostoses (multiple)-like 2(Extl2)
-
Protein short names
Extr2
-
Uniprot ID
Q9ES89
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the Mouse Extl2/Extr2 Asn43-Met330 is expressed with a 6His tag at the N-terminus.
-
Protein Species
Mouse
-
Purity
>95% as determined by SDS-PAGE.
-
Validations
Mouse Extl2/Extr2 (His tag) recombinant protein
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"