Mouse CXCL10 recombinant protein (C-His)

Mouse CXCL10 recombinant protein (C-His)

• DataSheet
• Material Safety Data Sheets (MSDS)

CXCL10, also known as crg-2, is a chemokine of the CXC subfamily and ligand for the receptor CXCR3. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL10 has a three-dimensional crystal structure. Its signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. CXCL10 can be secreted by several cell types in response to IFN-γ. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy

C-X-C motif chemokine 10

C7,CRG-2,gIP-10,Ifi10,INP10,IP-10,IP10,mob-1,Scyb10

P17515

C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-IP10; IP-10; C7; Interferon-gamma induced protein CRG-2; Small-inducible cytokine B10

Yeast

A DNA sequence encoding the mouse CXCL10 (NP_067249.1) (Ile22-Pro98) was expressed with a polyhistidine tag at the C-terminus.

Mouse

The recombinant mouse CXCL10 consists of 87 amino acids and predicts a molecular mass of 10.1 kDa.

> 90 % as determined by SDS-PAGE.