-
Product Name
Mouse CD99 (Fc Tag) recombinant protein
- Documents
-
Description
The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD99 is a transmembrane protein expressed on most hematopoietic cells, endothelial cells and at the borders between confluent cells. CD99 is also found expressed in the development of normal ovary and testis as well as in 25 sex cord-stromal tumors, 7 epithelial neoplasms, and 6 germ cell tumors. CD99 may be a useful marker for sex cord-stromal tumors and that its degree of reactivity correlates with the degree of differentiation in Sertoli-Leydig cell tumors. Additionally, CD99 might aid in distinguishing granulose cell tumors of the ovary from poorly differentiated carcinomas and it has been reported to be a sensitive and specific marker for Ewing's sarcoma and primitive neuroectodermal tumor.
-
Protein name
CD99 antigen-like protein 2
-
Protein short names
MIC2X; D4; MIC2Y; MIC2; 1110061M03RIK; MSK5X; CD99; PILR-1; PILR-L; HBA71; 2410026K10RIK
-
Uniprot ID
Q8BIF0
-
Gene Name
Cd99l2; Mic2l1
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the mouse CD99 (NP_612182.1) extracellular domain (Met 1-Gly 137) was fused with the Fc region of human IgG1 at the C-terminus.
-
Protein Species
Mouse
-
Molecular weight
The recombinant mouse CD99/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 350 amino acids and predicts a molecular mass of 37.5 kDa. As a result of glycosylation, the apparent molecular mass of rm CD99/Fc monomer is approximately 47-55 kDa in SDS-PAGE under reducing conditions.
-
Purity
> 90 % as determined by SDS-PAGE
-
Validations
Mouse CD99 / PILR1 Protein (Fc Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"