MLXIPL antibody

MLXIPL antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MLXIPL Rabbit Polyclonal antibody. Positive WB detected in HepG2 cells, HeLa cells, human liver tissue. Positive IP detected in HepG2 cells. Observed molecular weight by Western-blot: 65 kDa

ELISA, WB, IP

Human; other species not tested.

bHLHd14 antibody; CHREBP antibody; MIO antibody; MLX interacting protein like antibody; MLX interactor antibody; MLXIPL antibody; MONDOB antibody; WBSCR14 antibody; WS bHLH antibody

Rabbit IgG

This antibody was obtained by immunization of MLXIPL recombinant protein (Accession Number: BC012925). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Carbohydrate response element-binding protein (ChREBP), also known as MLXIPL, is a glucose-responsive transcription factor that has a fundamental role in the glucose-mediated induction of genes involved in hepatic glycolysis and lipogenesis. Circulating blood glucose levels affect ChREBP activity in hepatocytes largely by post-translational mechanisms that include phosphorylation-dependent subcellular localization [PMID:21665952]. It enhances expression of the liver pyruvate kinase (LPK) gene and all lipogenic enzyme genes resulting in the conversion of excess dietary carbohydrate into triglycerides that can be stored as fat [PMID:15118080]. Molecular Weight of ChREBP splice variants: 62/78/91/93 kDa.