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Product Name
MLN64 antibody
- Documents
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Description
MLN64 Rabbit Polyclonal antibody. Positive IP detected in MCF-7 cells. Positive WB detected in MCF7 cells, mouse brain tissue, mouse placenta tissue. Positive IHC detected in human ovary tumor tissue. Observed molecular weight by Western-blot: 48-53 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CAB1 antibody; MLN 64 antibody; MLN64 antibody; Protein CAB1 antibody; STARD3 antibody
- Immunogen
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MLN64 recombinant protein (Accession Number: XM_047435165). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:112685(MLN64,STARD3 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:112685(MLN64,STARD3 antibody) at dilution of 1:200 (under 10x lens)
Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:112685(MLN64,STARD3 antibody) at dilution of 1:200 (under 40x lens)
IP Result of anti-MLN64,STARD3 (IP:Catalog No:112685, 3ug; Detection:Catalog No:112685 1:500) with MCF-7 cells lysate 1200ug.
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Background
MLN64 (also known as STARD3) is an integral membrane protein anchored in late endosomes. MLN64 has a StAR-related lipid-transfer (START) domain to bind cholesterol, mediating intracellular cholesterol transfer. MLN64 is widely expressed in multiple tissues including liver, spleen, heart, kidney, lung, and the brain. Higher expression of MLN64 has been found in several malignancies.
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References
- Liu R, Li J, Zhang T. Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking. Autophagy. 10(7):1241-55. 2014.
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