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  • Human MAP4K2/GC Kinase (His & GST Tag) recombinant protein

Human MAP4K2/GC Kinase (His & GST Tag) recombinant protein

Cat.#: 502950

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Product Information

  • Product Name
    Human MAP4K2/GC Kinase (His & GST Tag) recombinant protein
  • Documents
  • Description
    Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion.
  • Protein name
    Mitogen-activated protein kinase kinase kinase kinase 2
  • Protein short names
    MGC143894; GCK; BL44; RAB8IP; AI385662; MAP4K2; MGC143893; GC KINASE
  • Uniprot ID
    Q12851
  • Gene Name
    MAP4K2; GCK; RAB8IP
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human MAP4K2 (AAH47865.1) (Met 1-Tyr 812) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human MAP4K2/GST chimera consists of 1049 amino acids and has a calculated molecular mass of 119 kDa. It migrates as an approximately 116 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 87 % as determined by SDS-PAGE
  • Activity
    Kinase activity untested
  • Validations

    Human MAP4K2 / GC Kinase Protein (His & GST Tag) SDS-PAGE

    Human MAP4K2 / GC Kinase Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"