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mGluR1 antibody

Cat.#: 112600

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Product Information

  • Product Name
    mGluR1 antibody
  • Documents
  • Description
    mGluR1 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue, mouse brain tissue. Positive IHC detected in mouse brain tissue. Observed molecular weight by Western-blot: 54 kDa,102 kDa
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    GPRC1A antibody; GRM1 antibody; GRM1A antibody; mGlu1 antibody; mGluR1 antibody; MGLUR1A antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_000838). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:1000

    IHC: 1:50-1:500

  • Validations

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:112600(GRM1 antibody) at dilution of 1:300

    human brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:112600(GRM1 antibody) at dilution of 1:300

    Immunohistochemistry of paraffin-embedded mouse brain tissue slide using Catalog No:112600(GRM1 Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded mouse brain tissue slide using Catalog No:112600(GRM1 Antibody) at dilution of 1:200 (under 10x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded mouse brain tissue slide using Catalog No:112600(GRM1 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

    Immunohistochemistry of paraffin-embedded mouse brain tissue slide using Catalog No:112600(GRM1 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

  • Background
    GRM1, also named as GPRC1A and MGLUR1, belongs to the G-protein coupled receptor 3 family. GRM1 is a receptor for glutamate. The activity of GRM1 is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. It may participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. The antibody can recognize isoform1 and isoform2 of GRM1.
  • References
    • Koochekpour S, Majumdar S, Azabdaftari G. Serum glutamate levels correlate with Gleason score and glutamate blockade decreases proliferation, migration, and invasion and induces apoptosis in prostate cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 18(21):5888-901. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"