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Product Name
MGAT4C antibody
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Description
MGAT4C Rabbit Polyclonal antibody. Positive WB detected in SH-SY5Y cells, mouse testis tissue. Positive IP detected in mouse testis tissue. Observed molecular weight by Western-blot: 55 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
GlcNAc T IVc antibody; GnT IVc antibody; GNTIVH antibody; HGNT IV H antibody; MGAT4C antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MGAT4C recombinant protein (Accession Number: XM_017019150). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:1000
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Validations
SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:112539(MGAT4C antibody) at dilution of 1:300
IP Result of anti-MGAT4C (IP:Catalog No:112539, 4ug; Detection:Catalog No:112539 1:400) with mouse testis tissue lysate 4000ug.
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Background
MGAT4C is predicted to be a glycosyltransferase that catalyzes a GlcNAc β1-4 linkage to the core mannose residues of N-glycans, resulting in N-glycans with tri- or tetraantennary structures.Recently MGAT4C has been found to get involved in processing complex N-glycan structures on CD133 and CD133 has been identified as a substrate of MGAT4C. Given to the fact that CD133 is widely used as a marker of numerous stem cell and cancer stem cell types, MGAT4C may have an important role in certain cancers.(21937449)
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References
- Mak AB, Blakely KM, Williams RA. CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope. The Journal of biological chemistry. 286(47):41046-56. 2011.
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