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Product Name
MED19 antibody
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Description
MED19 Rabbit Polyclonal antibody. Positive IHC detected in human testis tissue. Positive WB detected in human testis tissue. Observed molecular weight by Western-blot: 31 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
DT2P1G7 antibody; LCMR1 antibody; MED19 antibody; mediator complex subunit 19 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MED19 recombinant protein (Accession Number: NM_153450). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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Validations
human testis tissue were subjected to SDS PAGE followed by western blot with Catalog No:112586(MED19 antibody) at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:112586(MED19 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:112586(MED19 Antibody) at dilution of 1:50 (under 40x lens)
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Background
Mediator of RNA polymerase II transcription subunit 19 (MED19) is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (PMID: 12584197). Mediator complex is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (PMID: 15175163). MED19 may be a novel proliferation regulator that promotes lung cancer and gastric cancer progression and cellular growth (PMID: 21519921)(PMID: 22565189).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"