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Product Name
MED10 antibody
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Description
MED10 Rabbit Polyclonal antibody. Positive WB detected in COLO 320 cells. Observed molecular weight by Western-blot: 16 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
MED10 antibody; mediator complex subunit 10 antibody; NUT2 antibody; TRG 17 antibody; TRG 20 antibody; TRG17 antibody; TRG20 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MED10 recombinant protein (Accession Number: NM_032286). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
COLO 320 cells were subjected to SDS PAGE followed by western blot with Catalog No:112581(MED10 Antibody) at dilution of 1:300
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Background
MED10, also named as L6, TRG17, or TRG20, is a 135 amino acid protein, which belongs to the Mediator complex subunit 10 family. MED10 localizes in the nucleus and as a component of the Mediator complex, a coactivator is involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Multiprotein mediator complex acting as a coactivator is required for activation of RNA polymerase II transcription by DNA bound transcription factors.
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References
- Vijayalingam S, Chinnadurai G. Adenovirus L-E1A activates transcription through mediator complex-dependent recruitment of the super elongation complex. Journal of virology. 87(6):3425-34. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"