MCL1L-specific antibody

MCL1L-specific antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

MCL1L-specific Rabbit Polyclonal antibody. Positive IHC detected in human spleen tissue, human brain tissue, human breast cancer tissue, human cervical cancer tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human skin tissue, human testis tissue, human tonsillitis tissue.

ELISA, IHC

Human,Mouse,Rat; other species not tested.

EAT antibody; Mcl 1 antibody; Mcl 1l antibody; Mcl 1s Delta TM antibody; MCL1 antibody; mcl1/EAT antibody; MCL1L antibody; MCL1S antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_182763). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. This antibody is specific to MCL1L isoform.