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Product Name
MBD5 antibody
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Description
MBD5 Rabbit Polyclonal antibody. Positive WB detected in mouse heart tissue, human skeletal muscle tissue, mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 160kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse, rat; other species not tested.
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Alternative names
MBD5 antibody; MRD1 antibody; KIAA1461 antibody; FLJ30517 antibody; FLJ11113 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MBD5 recombinant protein (Accession Number: BC014534). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:112505(MBD5 antibody) at dilution of 1:500
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Background
In vertebrates, cytosine methylation in DNA is one of the major epigenetic modifications, which regulates many cellular events, including developmental gene expression, X chromosome inactivation, genome defense, and genomic imprinting . DNA methylation exerts regulatory functions by recruiting specific binding proteins that contain a highly conserved methyl-CpG binding domain (MBD) [PMID:12610534,16403636]. Methyl-CpG binding domain protein 5 (MBD5) belongs to the MBD family proteins, which play central roles in transcriptional regulation and development. It is a candidate gene involved in human 2q23.1 microdeletion syndrome [PMID:23077600].
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"