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Product Name
Marcksl1 antibody
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Description
Marcksl1 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 60kd
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Tested applications
ELISA, WB
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Species reactivity
human, mouse; other species not tested.
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Alternative names
Marcksl1 antibody; D4Bc1 antibody; AW215397 antibody; Mrp antibody; Macs2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Recombinant Protein (Accession Number: NM_010807). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:112450(Marcksl1 antibody) at dilution of 1:500
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Background
MacMARCKS is a member of MARCKS family of PKC substrate. It is widely used in the signal transduction studies as an indictor of PKC activation. The protein has a calculated molecular weight of 20 kDa and an apparent molecular weight of 42-45 kDa in different species on SDS PAGE. MacMARCKS functions in many aspects of cell physiology including integrin activation, cell spreading and phagocytosis. Its functions are though to associate with its ability in binding and regulating actin and microtubule cytoskeleton. Current evidence indicated that this protein also involved controls membrane fluidity and molecular mobility of membrane proteins
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References
- Björkblom B, Padzik A, Mohammad H. c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells. Molecular and cellular biology. 32(17):3513-26. 2012.
- Ayyadurai S, Charania MA, Xiao B, Viennois E, Zhang Y, Merlin D. Colonic miRNA expression/secretion, regulated by intestinal epithelial PepT1, plays an important role in cell-to-cell communication during colitis. PloS one. 9(2):e87614. 2014.
- van den Bout I, Truong HH, Huveneers S, Kuikman I, Danen EH, Sonnenberg A. The regulation of MacMARCKS expression by integrin beta3. Experimental cell research. 313(6):1260-9. 2007.
- Wang J, Jarrett J, Huang CC, Satcher RL, Levenson AS. Identification of estrogen-responsive genes involved in breast cancer metastases to the bone. Clinical & experimental metastasis. 24(6):411-22. 2007.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"