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Product Name
Mouse MBL-1 (His Tag) recombinant protein
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Description
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).
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Protein name
Mannose-binding protein A
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Protein short names
ERGIC53; F5F8D; MR60; MBL1; MBL-A; S-MBP; FMFD1; MBP-A; ERGIC-53; MCFD1; GP58
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Uniprot ID
P39039
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Gene Name
Mbl1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of mouse MBL (NP_034905.1) (Ser 18-Ala 239) was expressed with a N-terminal polyhistidine tag.
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Protein Species
Mouse
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Molecular weight
The secreted recombinant mouse MBL consists of 238 amino acids and has a calculated molecular mass of 25.8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 32 kDa protein in SDS-PAGE under reducing conditions.
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Purity
> 92 % as determined by SDS-PAGE
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Activity
Using the Octet RED System, the affinity constant (Kd) of mouse MBL bound to biotinylated mannan was 72nM.
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Validations
Mouse MBL1 Protein (His Tag) SDS-PAGE
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