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Product Name
MAML3 antibody
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Description
MAML3 Rabbit Polyclonal antibody. Positive IF detected in HEK-293 cells. Positive WB detected in HEK-293 cells. Observed molecular weight by Western-blot: 122 kDa
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Tested applications
ELISA, WB, IF
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Species reactivity
Human; other species not tested.
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Alternative names
CAGH3 antibody; ERDA3 antibody; GDN antibody; KIAA1816 antibody; MAM 2 antibody; Mam 3 antibody; MAM2 antibody; MAML3 antibody; mastermind like 3 (Drosophila) antibody; Mastermind like protein 3 antibody; TNRC3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of MAML3 recombinant protein (Accession Number: NM_018717). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IF: 1:20-1:200
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:112461(MAML3 antibody) at dilution of 1:2000
Immunofluorescent analysis of HEK-293 cells using Catalog No:112461(MAML3 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Background
The three MAML genes are widely expressed in adult tissues but exhibit distinct expression patterns in mouse early spinal cord development. All MAML proteins localize to nuclear bodies, share a conserved basic domain in their N termini that binds to the ankyrin repeat domain of Notch, and contain a transcriptional activation domain in their C termini. MAML3 acts as a transcriptional coactivator for NOTCH proteins and has been shown to amplify NOTCH-induced transcription of HES1.
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