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Human PRNP / Prion protein (Fc Tag)

Cat.#: 500283

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Product Information

  • Product Name
    Human PRNP / Prion protein (Fc Tag)
  • Documents
  • Description
    May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
  • Protein name
    Major prion protein
  • Protein short names
    CD230; PRP< RP23-401J24.1; KURU; PRP27-30; C> PRP; PRPC; PRION-RELATED PROTEIN; ALTPRP; PRIP; CJD; ASCR; RP5-1068H6.2; PRN-I; PRPSC; P27-30; PRP33-35C; SINC; GSS; PRP; PRION PROTEIN; MAJOR PRION PROTEIN; AI325101; PRN-P; AA960666; CD230 ANTIGEN; PRNP; ASCR
  • Uniprot ID
    Q53YK7
  • Gene Name
    PRNP; ALTPRP; PRIP; PRP
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human PRNP (NP_000302.1) (Met1-Gly229) was expressed with the Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human PRNP/Fc comprises 448 amino acids and has a predicted molecular mass of 49.7 kDa. The apparent molecular mass of the protein is approximately 57.4 kDa in SDS-PAGE under reducing conditions.
  • Purity
    > 90 % as determined by SDS-PAGE
  • Validations

    Human PRNP / Prion Protein (Fc Tag) SDS-PAGE

    Human PRNP / Prion Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"