Human PRNP / Prion protein (Fc Tag)
May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Major prion protein
Protein short names
CD230; PRP< RP23-401J24.1; KURU; PRP27-30; C> PRP
; PRPC; PRION-RELATED PROTEIN; ALTPRP; PRIP; CJD; ASCR; RP5-1068H6.2; PRN-I; PRPSC; P27-30; PRP33-35C; SINC; GSS; PRP; PRION PROTEIN; MAJOR PRION PROTEIN; AI325101; PRN-P; AA960666; CD230 ANTIGEN; PRNP; ASCR
PRNP; ALTPRP; PRIP; PRP
A DNA sequence encoding the human PRNP (NP_000302.1) (Met1-Gly229) was expressed with the Fc region of human IgG1 at the C-terminus.
The recombinant human PRNP/Fc comprises 448 amino acids and has a predicted molecular mass of 49.7 kDa. The apparent molecular mass of the protein is approximately 57.4 kDa in SDS-PAGE under reducing conditions.
> 90 % as determined by SDS-PAGE
Human PRNP / Prion Protein (Fc Tag) SDS-PAGE
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